منابع مشابه
The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer.
Disappearance of the Barr body is considered a hallmark of cancer, although whether this corresponds to genetic loss or to epigenetic instability and transcriptional reactivation is unclear. Here we show that breast tumors and cell lines frequently display major epigenetic instability of the inactive X chromosome, with highly abnormal 3D nuclear organization and global perturbations of heteroch...
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We report herein a set of calculations designed to examine the effects of epigenetic modifications on the structure of DNA. The incorporation of methyl, hydroxymethyl, formyl and carboxy substituents at the 5-position of cytosine is shown to hardly affect the geometry of CG base pairs, but to result in rather larger changes to hydrogen-bond and stacking binding energies, as predicted by dispers...
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Existence and uniqueness theorems for unstable manifolds are well-known. Here we prove certain refinements. Let f : (C, 0) → C be a germ of an analytic diffeomorphism, whose derivative Df(0) has eigenvalues λ1, . . . , λn such that |λ1| ≥ · · · ≥ |λk| > |λk+1| ≥ · · · ≥ |λn|, with |λk| > 1. Then there is a unique k-dimensional invariant submanifold whose tangent space is spanned by the generali...
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Unstable angina has only been recognized as a distinct entity for about 50 years. The term is used to describe a symptom complex that is neither stable angina pectoris nor acute myocardial infarction. There are a number of other terms used to describe essentially the same symptom complex; these include pre-infarction angina, crescendo angina, intermediate coronary syndrome and threatening infar...
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this paper addresses the validity of two hypotheses concerning changes of vowel quality in persian. the theory of centralization claims that there is a strong correlation between vowel duration and vowel quality. as vowel duration is shortened in unstressed contexts, the size of the vowel inventory reduces toward the center, leading to considerable overlap between different categories and a red...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2001
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20010709-01